Fabian Ruiz is out with COVID-19, but Kostas Manolas makes a rapid recovery for Napoli, while Jose Callejon and Franck Ribery start for Fiorentina.
It kicks off at the Stadio Diego Armando Maradona at 11.30 GMT, you can follow all the build-up and action as it happens from today’s five Serie A games on the LIVEBLOG.
The Partenopei have stuttered recently and need to turn the tide, especially as the Italian Supercup with Juventus is coming up on Wednesday.
Fabian Ruiz won’t be able to take part in that either, as he tested positive for COVID-19 on Saturday evening.
This game usually would’ve been postponed by a few hours to get the other players tested on the day of the fixture, but with swabs taken last night, they were given the all-clear this morning.
Giovanni Di Lorenzo is suspended, with Victor Osimhen and Kevin Malcuit still out of action, but Kostas Manolas makes a lightning fast recovery to start.
Dries Mertens is on the bench and preparing for his comeback a month after his ankle sprain, but Chucky Lozano, Lorenzo Insigne and Andrea Petagna continue to lead the attack, with Diego Demme stepping into midfield.
Fiorentina have a full squad to choose from and coach Cesare Prandelli goes all-out attack with Callejon, Franck Ribery and Dusan Vlahovic.
Napoli: Ospina; Hysaj, Manolas, Koulibaly, Mario Rui; Demme, Bakayoko; Lozano, Zielinski, L Insigne; Petagna
Fiorentina: Dragowski; Igor, Milenkovic, Pezzella; Venuti, Amrabat, Castrovilli, Biraghi; Callejon, Ribery; Vlahovic