In addition to absentees Ismael Bennacer and Franck Kessie, Milan could have to cope without Sandro Tonali against Lazio on Wednesday.
La Gazzetta dello Sport writes the former Brescial midfielder struggles with a muscle problem, forcing him to quit halfway in the 2-1 win over Sassuolo on Sunday.
The report highlights the injury adds to the one of Bennacer and the suspension of Kessie, meaning Stefano Pioli could have three of his most important midfielders unavailable against the Biancocelesti.
The Rossoneri enter the final game of 2020 as League leaders in Italy, one point above local rivals Inter and a gap of 10 down to Lazio at eight in Serie A.
Milan and Juventus are the only two sides still unbeaten after 13 League games.